Literature
Lancet · 2025-10-17
FLUNITY-HD: influenza/pneumonia admissions 1,312/233,311 versus 1,437/233,009; relative efficacy 8.8% (95% CI 1.7–15.5); one-sided P=.0082.
Eur J Pharmacol · 2025-08-05
Rovadicitinib after ruxolitinib: n=9, single-arm Phase Ib; grade ≥3 thrombocytopenia 33.3%.
Blood · 2025-06-19
ATLAS-OLE: AT-guided dosing. Interim cohort n=213; integrated safety n=286. ABR comparable to prior factor prophylaxis; nonrandomized comparison.
Blood · 2025-06-12
Rovadicitinib cGVHD: n=44, single-arm; best response 86.4% (95% CI 72.6–94.8). Anemia 38.6%; grade ≥3 anemia 4.6%.
Blood · 2025-06-12
LUNA3: durable platelet response 31/133 versus 0/69 at 24 weeks. Continued treatment response-selected.
N Engl J Med · 2025-04-08
HERCULES: 754/377 randomized; disability-progression HR 0.69 (95% CI 0.55–0.88). Serious events 15.0%/10.4%; ALT >3× normal 4.0%/1.6%.
N Engl J Med · 2024-09-02
PALISADE: n=75; month-10 triglycerides −80%/−78% versus −17%. Pancreatitis OR 0.17 (95% CI 0.03–0.94).
N Engl J Med · 2024-06-03
IMROZ: 446 transplant-ineligible patients; 60-month PFS 63.2% versus 45.2%; HR 0.60 (98.5% CI 0.41–0.88).
J Allergy Clin Immunol · 2024-02-29
CUPID A: n=138, omalizumab-naive; UAS7 difference −8.5 (95% CI −13.2 to −3.9). CUPID B, n=108: primary endpoint missed.
N Engl J Med · 2024-02-15
Frexalimab: 129 randomized, 114 efficacy-evaluable; week-12 MRI rate ratios 0.11/0.21. Imaging endpoint.
N Engl J Med · 2023-12-28
HARMONIE: RSV hospitalization 11/4,037 versus 60/4,021; efficacy 83.2% (95% CI 67.8–92.0). Open-label; one season.
N Engl J Med · 2023-10-18
PROTECT: 217/111 randomized; week-78 C-peptide difference 0.13 pmol/mL (95% CI 0.09–0.17). Key clinical secondary endpoints nonsignificant.
NEJM Evid · 2023-05-23
PIONEER: 141/71 randomized; week-24 symptom-score change −15.6 versus −9.2. Tryptase reduction ≥50%: 76/141 versus 0/71.
N Engl J Med · 2023-05-21
BOREAS: 939 eosinophilic COPD exacerbators; exacerbation rate ratio 0.70 (95% CI 0.58–0.86), maximal inhaled treatment.
Nat Med · 2023-05-04
PRIME: week-24 itch response 45/75 versus 14/76. PRIME 2: week-12 response 29/78 versus 18/82.
N Engl J Med · 2023-01-26
XTEND: n=133; weekly prophylaxis mean ABR 0.71 (95% CI 0.52–0.97). Prestudy comparator: intrapatient.
N Engl J Med · 2022-12-22
EoE Part A, week 24: histologic remission 25/42 versus 2/39. Dysphagia improved with weekly, not every-two-week dosing.
N Engl J Med · 2022-03-03
MELODY: medically attended RSV-LRTI 12/994 versus 25/496; efficacy 74.5% (95% CI 49.6–87.1). Hospitalization CI crosses zero.
N Engl J Med · 2019-06-09
TN-10: progression in 19/44 teplizumab versus 23/32 placebo recipients.
Background wording corrected; endpoints unchanged ↗
N Engl J Med · 2018-11-07
ODYSSEY: 903/9,462 versus 1,052/9,462 cardiovascular events; HR 0.85 (95% CI 0.78–0.93). Injection reactions increased.
N Engl J Med · 2018-05-21
QUEST: n=1,902; annual severe-exacerbation rate 0.46 versus 0.87 with 200 mg dosing over 52 weeks.
N Engl J Med · 2016-09-30
SOLO 1/2: 671/708 adults; week-16 IGA response 38%/36% versus 10%/8%. Injection reactions and conjunctivitis increased.
Diabetes Care · 2016-08-15
LixiLan-O: n=1,170, open-label; week-30 HbA1c −1.6% combination, −1.3% glargine, −0.9% lixisenatide.
Glucose units corrected; efficacy unchanged ↗
N Engl J Med · 2012-06-11
ORIGIN: n=12,537; median 6.2 years. Cardiovascular outcomes neutral; severe hypoglycemia and weight gain increased.
Lancet · 1996-11-16
CAPRIE: n=19,185; annual vascular-event risk 5.32% versus 5.83%, aspirin 325 mg; relative reduction 8.7% (95% CI 0.3–16.5).
Unassessed corrections
Lancet · 2019-09-19
SINUS: correction unassessed.
Correction body unassessed ↗
Dec 2021
COMET: correction unassessed.
Correction ↗
Overlapping cohorts
Circulation · 2025-11-10
FLUNITY-HD secondary analysis; same 466,320 participants.
N Engl J Med · 2023-04-05
MELODY expanded cohort; overlaps original trial.